Exact(9)
Until recently, rare mutations have been hard to catalog because of the difficulty of distinguishing an unusual mutation from an error in the DNA decoding process.
It is important to notice that a copy without mutation from an ancestral sequence (e.g., ACAGATATA) results in the same sequence (not in its complement, i.e., TGTCTATAT).
We report here a possible transmission of a minor variant carrying an NNRTI resistance mutation from an ARV-naïve mother to a child and subsequent emergence of this variant as a dominant population during an NNRTI non-based ARV treatment.
The UAMS-1 sspA (SAR1022/SA0901) and sarA/sspA mutants were generated by Φ11-mediated transduction of the ssp::tet mutation from an existing 8325-4 mutant (kindly provided by Simon Foster, University of Sheffield) into UAMS-1 and UAMS-929 respectively.
One patient had inherited the mutation from an unaffected mother.
Sequencing of genomic DNA revealed a T-to-A transversion at nucleotide position 1151, causing a mutation from an isoleucine residue to an asparagine residue (I384N).
Similar(51)
Let the null mutation rate, or the rate of mutation from A to a, be u per gene per generation.
Yet something was afoot: there was rumbling under the arches around Clink Street, and Borough Market was beginning its mutation from a wholesale fruit-and-veg outlet into a retail chorizo and frothy coffee one.
The German labour market has "undergone a strange mutation from a bulwark of eurosclerosis into a champion of flexibility", writes Joachim Möller of the Institute for Employment Research (IAB).
_____ The May Genius puzzle (No 107 set by Puck) attracted another large entry, despite some controversy as to whether COLLEDIG is not a more usual translation in Welsh for 'lost' than GOLLWYD, which, of course, is a mutation from a declension of the verb COLLI ('to lose').
Katayama et al found a novel V1180L gatekeeper mutation from a cell line model and a novel I1171T secondary mutation from a patient who developed resistance to alectinib (Katayama et al., 2014).
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