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Combining our dataset with the Saccharomyces Genome Database phenotype term "mutation frequency: increased," we compiled the list of yeast genes with reported mutator phenotypes (Table S1).
Mutation frequency increased when the quantity of injected Hox5-sg1 was increased from 1.5 to 3.0 pg.
A previous report indicated that the induced mutation frequency increased with ENU dose dependently in mouse [ 36].
Compared with sham-treated controls, the Spi− mutation frequency increased 2.4-fold in non-targeted lung tissues at 24 h after partial body irradiation (PBIR).
In adenocarcinoma, K-Ras mutation frequency increased from 7 out of 55 (13%) by direct sequencing to 15 (27%) by clamped-PCR (P<0.005).
In adenocarcinoma, K-Ras mutation frequency increased from 7 out of 55 (13%) by direct sequencing to 15 out of 55 (27%) by clamped-PCR (P<0.005).
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Interestingly, mutation frequencies increased significantly (P<0.05) on exposure to H2O2 in the presence of higher CO2 levels (Fig 2).
Furthermore, there is some indication that mutation frequency increases with population age.
We think that a mutation frequency increase of 100,000× is remarkably high.
Moreover, in glial tumors, PTEN mutation frequency increases with increasing tumor grade and is associated with poorer outcome [ 52, 53].
TP53 mutation frequency increases consistently in the high-incidence regions reaching rates of over 80% in a high-risk area of France (Normandy) [ 19], 40 70% in China [ 20, 21], 50 65% in Northern Iran Tehrann) [ 22, 23] and an extremely high prevalence of 90% in North eastern Iran (Golestan province) [ 24].
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