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The mutation frequency for GPR14 was statistically significantly different as compared both to the RASSF1A and RBSP3 (P = 0.01).
Importantly, H2O2-induced mutagenesis in the mutS strain was still DinB-dependent (Fig. 3B), as we observed a more than 8-fold reduction in the H2O2-induced mutation frequency for the mutS dinB strain (3.3±1.9×10−6) compared to the mutS-deficient dinB+ strain (26.5±3.2×10−6).
The overall mutation frequency for sample no.
To compute the average mutation frequency for the entire testis, the mutation frequency for each piece was weighted by the number of genomes in each piece.
The overall mutation frequency for EMS was 1 SNP/967 kb.
Our TILLING population had quite a high mutation frequency for the COMT1 gene (1/92 kb).
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First, somatic mutation frequencies for commonly mutated components of the EGFR pathway (EGFR, KRAS, BRAF, PIK3CA and PTEN) were assessed in multiple solid cancer types.
The aim of the present investigation was to further establish mutation frequencies for genes commonly mutated in UC, and to investigate possible positive or negative associations between mutations.
As we did for the mutation frequencies for individual genes, we constructed the domain mutational landscape maps by plotting the domain mutation frequencies onto two-dimensional maps where each domain, not gene, is represented as a square of arbitrary size in a grid with coordinates in the x-y axes.
Mutation frequencies for each gene independently, and frequencies of combinations of mutations in the genes tested, were equally distributed between all stages.
Both techniques generate mutation frequencies for each position assayed, and both share limitations with respect to detection of co-occurring mutations.
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