Sentence examples for mutation frequency estimates from inspiring English sources

B-Raf mutations have also been identified in human cancers, including melanoma and thyroid, ovarian and colorectal tumours, although mutation frequency estimates in colorectal tumours vary from 1 to 20%, and have been particularly associated with tumours deficient in mismatch-repair activity (Wellbrock et al, 2004).

If we assume that the mutation frequencies estimated via H A and H0 are even approximately correct, D H A and D H 0 quantify the estimated robustness of R j k by averaging it over the range of expected nonsynonymous mutation counts.

The cellular compartment of blood was analyzed as an indicator of circulating tumor cells and the plasma was analyzed as an indicator of apoptotic/necrotic cancer-shedding membrane-encapsulated short DNA fragments in the circulation [23], [24].The mutation frequency was estimated at about 4 molecules per milliliter of plasma at pretreatment and within 24 hours after first treatment.

"Regenerant" mutation frequency was estimated as follows.

The average mutation frequency was estimated to be one mutation per 480 kb.

Mutation frequency was estimated as the total number of confirmed mutations divided by the total number of base pairs screened [ amplicon size - 200 bp) × individuals screened)].

Because 2/3 of indel mutants can be detected with the lacZ disruption assay, the indel mutation frequency was estimated to be ∼59%.

In the SMART mutant population, the mutation frequency was estimated to be 1/480 kb similar to the recently published reports in sunflower (1/475, [ 24]) and other crops (Arabidopsis 1/300 kb, Soybean 1/250 kb, Rice 1/265 kb, Tomato 1/322 kb; reviewed by [ 3]).

The over-prediction of BRCA1 mutations does not seem to be due to the mutation frequency or penetrance estimates used in the models.

The mutation frequencies were estimated to be 0.042% for BRCA1 and 0.054% for BRCA2.

The overall procedure of using nucleotide mutation frequencies to estimate codon mutation frequencies was first suggested by Deminoff et al. who argued that adequate statistical power could not be realized if only codon-triplet mutations were analyzed.