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Thus, tamoxifen injection may lead to a modest increase in liver DNA mutation frequency but it does not affect overall longevity or tumor susceptibility.
The laboratory selection experiment found that L1014F mutation frequency, but not L1014S mutation, responded to deltamethrin selection, suggesting that the L1014F mutation is the key mutation conferring resistance to deltamethrin.
Higher ENU concentrations not only increase the mutation frequency, but also affect fertility [ 5, 21].
They found that subgroups differ not only in TP53 mutation frequency but also in mutation types and consequences.
Hence, more severe mutation protocols can increase mutation frequency, but they also reduce the recovery of viable seeds dramatically.
This subgroup did not differ significantly with respect to TP53 mutation frequency, but was depleted of FGFR3 mutations (1 of 24 tumors, P = 0.0002).
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Studies of other transgenic assays have shown that time after treatment is a very important variable in the analysis of mutation frequencies but that eventually a plateau frequency is reached, indicating that the mutations are neutral.
In fact, elimination of G5SSR426 by site directed mutagenesis not only significantly reduces the mutation frequency in mucA, but also makes mucA to be no longer the major pathway for mucoid conversion [52].
Such a transformation considers mutation frequency absolute difference but being penalised by node degrees, thus fully utilising the information contained in the network.
Vandin et al. (2012) perform a significance test simulating a null model by independently permuting the mutations of each gene across patients, thus preserving the mutation frequency gene-wise (but not sample-wise).
Analysis results show that degree is not associated with mutation frequency or gene length but is positively correlated with the number of exons (R = 0.13, P = 0.02, Spearman's correlation).
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