Three days after transient transfection of the [GT/CA]19 construct, plasmids were recovered from HCT116 cells and analyzed for mutation frequency and mutational specificity.
Yeast-null mutants of RAD27 (RTH1) Flap endonuclease, an enzyme required for lagging strand DNA synthesis and DNA repair, display an increased microsatellite mutation frequency and a mutational bias favoring expansion mutations within [GT/CA] microsatellites.
We performed a pooled analysis of the complete data from these studies, at the levels of both induced mutation frequency and the resulting mutational spectrum.
These characters are believed to increase mutation frequency and mutation spectrum of plants or mammalian cells irradiated by heavy ions.
Previous studies have suggested that H2O2 affected KatG mutation frequency and caused changes in resistance to isoniazid (INH) (Timmins and Deretic, 2006).
We have discussed how carcinogenic contexts from chemicals, to radiation, to aging, can promote cancer evolution both by increasing mutation frequency and by promoting selection for adaptive mutations.
The mutagenic properties of bitumen fumes were determined by analyzing the mutation frequency and spectrum of the neutral reporter gene cII inserted into the rodent genome.
As such, the associations of node degree with node length, mutation frequency, and number of exons were further investigated.
Our analysis of the length of the period of prophylaxis in the low and high resistance settings of Navrongo, Ghana and Korogwe, Tanzania respectively provide further insight into the mechanism underlying the relationship between mutation frequency and protective efficacy.
This property presumably enhances the mutation frequency and increases the likelihood of malignant changes.
We further examined the correlation between the mutation frequency and degree of proteins using Pearson's correlation.
