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A similar behavior is seen with mutation frequency dependent on particle fluence.
We found that there was almost no effect of microgravity on DNA replication and mutation frequency.
However, the mutation frequency of the NC4 spores formed in space was similar to that of the ground control.
Inhibition of repair could result in an increase in the mutation frequency of the base damage.
The hub activity exhibits an abrupt change depending on the mutation frequency.
These characters are believed to increase mutation frequency and mutation spectrum of plants or mammalian cells irradiated by heavy ions.
"Finding this high mutation frequency is a breakthrough in the field of melanoma research," he says.
Probabilities of mutation frequency differences were calculated using Poisson distribution.
Because gene mutation frequency is significantly correlated with gene length (R = 0.4, P = 5.16×10−14, Spearman's correlation), gene mutation frequency was further corrected by gene length using formula "original mutation frequency/gene length".
42 amino acid mutations and 107 silent mutations (mutation frequency ≥5%) were included in the analysis.
We next investigated whether overexpression of the hPolλ W438 variant could affect mutation frequency in vivo.
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