At one extreme, 78 of the cancer genomes could have 50%% or more of the mutation frequencies in their SAMMs accounted for by the set of four canonical mutational mechanisms.
Influence of imatinib on mutation frequencies in Bcr-Abl-positive and Bcr-Abl-negative cells.
We initially confirmed this hypothesis by measuring mutation frequencies in experimental tumors using a lambda-based chromosomal shuttle vector reporter system.
ESTR mutation frequencies in the germline and somatic tissues of male and female mice irradiated at 12 days of gestation remained highly elevated during adulthood, which was mainly attributed to a significant increase in the frequency of singleton mutations.
Our method uses classical diffusion approximations to model temporal fluctuations in the selection coefficients to find the expected distribution of mutation frequencies in the population.
The thrombophilic allele mutation frequencies in our sample were not significantly different from predicted weighted average values: FVL, 2.8% versus 1.5%; PT, 1.7% versus 1.1%; and MTHFR, 24.7% versus 24.4%.
We used available estimates of BRCA1 mutation frequencies in the general population and age-specific incidence rates of breast and ovarian cancers in carriers and noncarriers of mutations to estimate the probability that a particular member of the family carries a mutation.
In the present series of primary cancers, mutation frequencies in these four genes were equally distributed between all tumor stages.
Moreover two other TSGs from these regions could cause increasing mutation frequencies in tumors (MLH1 from AP20 and G21/NPRL2 from LUCA) [11], [12], [13].
Experiments involving P. aeruginosa ΔmutS and ΔmutL strains show that enhanced mutation frequencies in P. aeruginosa can promote microcolony growth within biofilms (Figures 2 and 3).
For example, HIV-1 mutation frequencies in the envelope gene increase by 40-90% (including private and non-private changes) in cell culture following exposure to KP1212 [15].
