Sentence examples for mutation frequencies have from inspiring English sources
Mutation frequencies have therefore been explained by founder effects and population history [8].
Similarly, small increases in viral mutation frequencies have been shown to be associated with population collapse in other viral systems, including Vesicular Stomatitis, polio, Hepatitis C, Hantaan and foot-and-mouth disease [18] [25].
Specific BRCA1 and BRCA2 mutations or different mutation frequencies have been identified in specific populations and ethnic groups.
High Tp53 mutation frequencies have indeed been detected in metastatic and CR CaP, with 52 89% of tumors expressing Tp53 protein by IHC (Olivier et al., 2009).
Likewise, high mutation frequencies have been suggested as the cause of the frequently acquired antibiotic resistance during treatment of H. pylori infections (Bjorkholm et al., 2001).
In sporadic breast cancers, high TP53 mutation frequencies have been significantly associated with two polymorphisms: the homozygous Arginine at codon 72 of p53 (10); and the presence of the highly active allelic variant G of glutathione-S-transferases (GSTs) (11).
Inactivation of the OGG1 gene may lead to a higher risk of cancer because cells with accumulated 8-OH-G adducts still retain the ability to proliferate and a substantial increase of spontaneous mutation frequencies has been clearly identified in the DNA of mutant mice, bearing transgenic gene when exposed to exogenous carcinogens or endogenous oxidative species [ 6].
However, PIK3CA mutations frequencies have not been reported in the Middle Eastern CRCs.
It is possible that mutation frequency has been underestimated due to the lack of wide genetic epidemiology.
However, a direct correlation between the occurrence of particular mutations in mut genes and altered mutation frequency has not been proven.
However, it has to be noted that in zebrafish, which lack Msh6, no difference in ENU-induced mutation frequency has been observed compared to MMR-proficient fish [ 26].
