Thus, tamoxifen injection may lead to a modest increase in liver DNA mutation frequency but it does not affect overall longevity or tumor susceptibility.
The laboratory selection experiment found that L1014F mutation frequency, but not L1014S mutation, responded to deltamethrin selection, suggesting that the L1014F mutation is the key mutation conferring resistance to deltamethrin.
Higher ENU concentrations not only increase the mutation frequency, but also affect fertility [ 5, 21].
They found that subgroups differ not only in TP53 mutation frequency but also in mutation types and consequences.
Hence, more severe mutation protocols can increase mutation frequency, but they also reduce the recovery of viable seeds dramatically.
This subgroup did not differ significantly with respect to TP53 mutation frequency, but was depleted of FGFR3 mutations (1 of 24 tumors, P = 0.0002).
Cell lines from the oesophagus and urinary tract showed a somewhat lower mutation frequency, but in all cases higher than 25%.
In Xenopus, mismatches at the core region of sgRNA named "seed" sequence significantly influenced the mutation frequency, but the other regions are basically resistant to single nucleotide mismatches.
The "*" next to the CortBP2 domain denotes that the domain did not reach the threshold for significant mutation frequency, but ranked in the top 75 highest mutation frequency domains.
Although within-site sample sizes are low, it is worth noting that the TreeSAAP analysis is not based on mutation frequencies within populations, but upon the sequences themselves, and so is less affected by sampling strategy than approaches such as dN:dS ratios [ 56].
