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The amount of unknown TPO transcripts in the mutation free individuals was estimated in the range of 14.5 to 27%.
The accumulation of deleterious mutations is driven by rare fluctuations that lead to the loss of all mutation free individuals, a process known as Muller's ratchet.
The alignment of the minisatellite maps includes the operations of replacement (match/mismatch, where mismatch corresponding to mutation), free insertion/deletion (indel), and duplication.
The fitness of such a population in mutation-selection balance, relative to a mutation free population, is then W ¯ MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaqdaaqaaiabdEfaxbaaaaa@2DF4@.
Provided this condition is fulfilled, a population will approach a selection mutation balance in which the fraction of individuals contained within the best (deleterious mutation free) class is e − U / s (Haigh 1978), so the long-term effective population size is approximately N a = Ne − U / s, where N is the actual number of adults.
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A substantial part (the duplicate genes) of the human Y can therefore restore deleterious mutations-free haplotypes and the chromosome as a whole also tends to get deleterious mutations free.
In the fullness of time, perhaps men will think likewise and have some of the sperm of their carefree, mutation-free youths frozen in case they fancy a little procreation in their old age.
The embryos resulting from these mutation-free oocytes were replaced, yielding a singleton clinical pregnancy and birth of a healthy child following confirmation by prenatal diagnosis.
The method for pre-selection of mutation-free oocytes for LCHAD deficiency was developed by testing the first and second polar body removed from oocytes by micromanipulation techniques in the framework of in-vitro fertilization.
In the case of PPARγ, use of a transcriptional repressor designed to downregulate the expression of two PPARγ isoforms allowed "mutation-free reverse genetics" analysis that illuminated a unique role for the PPARγ2 isoform in adipogenesis (Ren et al., Genes Dev 2002 16:2002 16
The CTG tract was mutation-free when sequenced from each end to a distance of ∼300 bp, after which significant compressions were observed.
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