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However, what strikes us is that OspC itself, after mutation, fails to protect B. burgdorferi against innate elimination.
Consistent with the above data, full length CHIP with the K30A point mutation fails to bind to the ARM-ANK-LRR domains of LRRK2 (Supplemental Figure S2G).
Furthermore, the D620N mutation fails to significantly alter the vesicular localization of human VPS35 (Fig. 2B C).
The identified gephyrin‐G375D mutation fails to form postsynaptic clusters in neurons and acts dominant‐negatively on WT‐gephyrin.
Although the human GATA3 C318R mutation fails to bind DNA in vitro (Nesbit et al., 2004), it is possible that, in vivo, higher-order protein complexes compensate for this reduced DNA-binding capacity.
Vague, because merely presenting the term "interaction" and statements that alleles from different loci must interact in the determination of mutation fails to give the reader any clue to the molecular genetic mechanisms of allele interactions (alleles merely being variants of genes and not genes or retroposons etc. per se) and how they could modify an additional locus in a heritable mode.
Similar(53)
In addition, the bax null mutation failed to rescue expression of the dopaminergic phenotype in a subset of NG and PG neurons.
Conclusion: In contrast to sequential cross-sectional studies of children with CF, the present longitudinal study of children with homozygous for the ΔF508 mutation failed to confirm normalisation of growth over time.
Embryos homozygous for the endoglin mutation fail to progress beyond 10.5 days postcoitum and fail to form mature blood vessels in the yolk sac.
However, alleles at genes far away from the original mutation fail to hitchhike and show more typical levels of genetic variation (see Fig. 1).
In contrast, seam cells harboring the let-7 mutation fail to finish the L4-to-adult transition and instead exhibit extra cell division without proper formation of the adult alae (Reinhart et al., 2000).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com