Sentence examples for mutation experiment demonstrated from inspiring English sources

Mutation experiment demonstrated that two cis-acting elements in SHP-1 promoter were required for the induction of SHP-1 transcription by HNF1α (Supplementary information, Figure S7D).

When it comes to the receptor structure, mutation experiments demonstrated that Arg, His, Arg and Arg play an important role in receptor function.

Moreover, a careful analysis of AQP sequences alignment and mutation experiments demonstrated that the single substitution of the Asn-60 with a Gly residue eliminates the anion permeability and greatly enhances the osmotic water permeability [ 18].

NMBD deletion or mutation experiments demonstrate that either in the absence of the segment or in the presence of the segment with no Cu+ bound, no catalytic turnover is observed.

Fine epitope mapping using short synthetic peptide fragments and mutation experiments have demonstrated that the main epitope on β2GPI-DI is located around amino acid 40 of the molecule with R39-R43 representheg the key constituent of the discontinuous epitope [ 68].

The experiment demonstrated that automation affects workload.

This experiment demonstrates that the Y141C mutation does not affect binding to HJV.

Both calculation and experiment demonstrate that the gatekeeper mutation V561M in FGFR1 reduces the binding affinity for PD173074.

For us this experiment demonstrates a reproducible effect of a mutation of H3K64 on gene expression.

GST pull-down experiments demonstrated that mutation of hydrophobic residues in CALMANTH that participate in VAMP8 binding, Leu219Ser, Phe240Ala, Met244Lys, Ile247Asp, and Leu251Ser, all abolished the interaction between the two proteins in vitro without affecting the fold (as judged by expression levels and circular dichroism, data not shown).

We have successfully generated double mutations, double deletion and N-terminal deletion and C-terminal insertion mutants simultaneously in a single experiment, demonstrating that this modified method is efficient for multiple site-directed mutagenesis.