Sentence examples for mutation expected to from inspiring English sources
The H49Q mutation, expected to maintain hydrogen-bonding capabilities, restores only 16-fold of the 2190-fold k2 loss for krel (SRL) observed for the H49A mutant.
To test the importance of this pocket for the inhibition of ASICs, we introduced a mutation expected to close the pocket (T182W).
These oscillations are, in the absence of random genetic drift and mutation, expected to continue indefinitely, otherwise fixation or extinction of one of the two phenotypes occurs [ 22].
In 2008, a germline frameshift mutation, expected to disrupt the polymerase activity, was identified in one patient with a personal and familial history of breast cancer.
Based on Canavanine resistance assays, each strain was estimated to contain 47 ± 17 (99% confidence interval) EMS-induced point mutations, with exactly one mutation expected to affect YFP expression in 98.7% of the strains (Gruber et al. 2012).
These findings also complement other reports that single sodium channel mutations can result in multiple phenotypes giving rise to an 'overlap syndrome' as well as unique isolated phenotypes in which a mutation expected to result in a gain-of-function results in phenotypes that include changes suggestive instead of a loss-of-function.
Some examples of mutations expected to result in complete disruption of ribosomal function are contained within the 'expectedly disruptive' category.
One possibility of circumventing this problem is to make use of a predefined list of mutations expected to have the most significant effect on the therapy's outcome.
Moreover, the phenotypes of ITS2 mutations expected to block these interactions confer processing defects similar to those seen in A3-cluster mutants.
We have previously determined that less than 10% of the mutations expected to produce fragments that migrate in these ranges are identified [ 18].
The bioinformatics pipeline identified mutations expected to have deleterious impact on protein function based on PolyPhen predictions and conservation scores (Genomic Evolutionary Rate Profiling).
