Even, the case carrying the A3243G mutation exhibits normal tumour histology and low overall oxidative capacity.
In contrast, the jp (jimpy) mouse with a Plp1 missense mutation exhibits normal mitochondrial function.
Consistent with previous data (Mombereau et al., 2010), C57BL/6 mice with the INI mutation exhibit normal anxiety behaviour, but here we have shown that they have decreased depressive-like behaviour and fear-associated behaviours.
Because this mutation causes a premature termination, the production and function of the protein would be altered and such alteration was inherited from the consanguineous parents who carried the heterozygous deletion mutation but exhibited normal phenotype.
However, we identified a group of tumours with p53 gene mutations that exhibited normal or higher levels of p21 CIP1/WAF1 mRNA.
However, the even more dramatic scenarios lacking both MMR and BER (i.e. Msh2−/−Ung−/− [34] and Msh6−/−Ung−/− [35]) also exhibited normal overall mutation frequencies, suggesting that the mechanisms downstream of AID do not introduce additional mutations but rather modulate the initial spectrum.
Cells cotransfected with previously identified pore-loop missense mutations,W276S and G285C, as well as the exon 4 deletion exhibited normal protein synthesis and membrane expression of the ion channel, but there was no appreciable ion flow through the membrane.
Normal cochlear development was observed in Lgr5 EGFP/EGFP) and Lgr5 EGFP/+) mice, which exhibited normal auditory thresholds.
oriens and alveus typically exhibited normal dendritic morphology.
Control Otx2flox/CreERT2 animals exhibited normal retinal histology.
