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Flies bearing this mutation exhibited low levels of roX RNAs, indicating that these RNAs failed to associate with the proteins of the complex and were degraded, or that MLE contributes to their synthesis.
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In addition, two lung cancer cell lines with KRAS mutations exhibited low RAS pathway signature scores and were resistant to MEK inhibition, suggesting that while they are KRAS mutant, they are not dependent on RAS signaling.
Given that a few of the R201H and other mutation case subjects exhibited low normal scores, it may be that the VMI is not sensitive enough to quantify mild subclinical difficulty.
When we considered the case that a new advantageous mutation has fixed, rMHH and rHH exhibited low values regardless of the way of homozygosity estimation as shown in Fig. 2A and B, respectively.
The vast majority of nonamer positions exhibited low to moderate entropy (≤1.0), indicating lower probability of mutations occurring over time.
All compounds exhibited low antitumor activity.
On the contrary, TIMP2 exhibited low expression levels.
The six primer pairs exhibited low polymorphism.
L929, Swiss 3T3 and CSML0 exhibited intermediate levels, and N2a, CSML100 and HeLa exhibited low levels.
The C228T mutations seem to exhibit low sensitivity in conjunction with high specificity toward biologically aggressive disease; the latter providing a promising platform for further studies assessing TERT promoter mutations as a potential malignancy marker in equivocal cases with unknown malignant potential.
Furthermore, RNA editing sites are most stable in a base context that exhibits low mutation rates.
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