Sentence examples for mutation exerts a from inspiring English sources

The first is that the Mstn loss-of-function mutation exerts a maternal effect such that muscle mass of the fetus is influenced by the number of functional Mstn alleles in the mother.

It is therefore possible that the naturally-occurring MBD4 mutation exerts a dominant negative effect, where the truncated protein is not only defective in glycosylase activity, but also can inhibit normal MBD4 function via competitive binding of mismatch sites.

The AEC mutation exerts a selective dominant-negative function on wild-type p63 by affecting progenitor cell expansion during ectodermal development leading to a defective epidermal stem cell compartment.

The p63 AEC mutation exerts a selective dominant-negative function on wild-type p63 by affecting the expression of a number of p63 target genes, including Fgfr2 and Fgfr3.

Interestingly, the two mutations, R61T and E255A, have opposite effects on the stability of the C-terminal domain; the former mutation exerts a destabilizing effect and the latter exerts a stabilizing one such that the C-terminal domain stability of the apoE4 E255A variant is similar to that of apoE3.

PIK3CA carrying a hotspot mutation exerts an oncogenic activity: it can transform primary fibroblasts in culture, induce anchorage-independent growth, and cause tumors in animals [ 13, 14].

We again observed that the recq4a mutation exerted a marginal effect on flowering time; however, there was no interactive effect between the recq4a mutation and the MAF4 genotype (Table S7).

Thus, there exists a possibility of this missense mutation exerting a sufficiently strong dominant negative effect on the protein function, which does not necessitate the presence of the second hit NF2 gene inactivating event in this tumor.

Moreover, when co-expressed with the wild-type subunit (to mimic the heterozygous state) the T428I mutation exerted a severe dominant negative loss-of-function phenotype, reducing overall channel activity to below 50% of that seen with the wild-type channel alone (Fig. 4B).

> -wrap-foot> OPA1 mutations exert a deleterious effect on in vivo mitochondrial function, irrespective of mutational subtypes and disease severity.

The mechanism by which PRKN mutations exert a pathogenic effect is not fully understood, but may involve loss of function and inhibition of parkin's ubiquitin E3 ligase activity and consequent enhancement of neurodegeneration via impaired ubiquitination of substrates [15].