Sentence examples for mutation especially in from inspiring English sources

As the virus appeared in its most virulent form in 2006, it is expected that any significant mutation, especially in the multibasic aa sequence, should lead to lower virulence.

Without a controlled vocabulary or a clear definition of what constitutes an activating mutation, especially in the case of mutations with multiple known phenotypes, systematic identification will continue to be a challenge.

For example, the behavioral effect of any given mutation, especially in a gene that could be involved in a complex disorder, could depend on the age and genetic background of the organism.

Although L110P may be a frequent mutation, especially in Japanese patients, there were no marked differences in the clinical picture between L110P/E148Q and E148Q alone.

The second issue when using these agents is that they paradoxically activate the MAPK pathway in cells devoid of BRAF mutation, especially in the presence of an additional somatic event occurring in this pathway, such as a RAS mutation.

These disorders commonly result from constitutive activation of JAK2 signalling through mutation of JAK2, frequently via the JAK2 V617F mutation (especially in polycythaemia vera), but also from JAK2 exon 12 mutations, or mutation of the TPO receptor (MPL), or mutations of LNK, a negative regulator of JAK2 [ 79– 81].

For example, the APOBEC genes encode DNA cytidine deaminases that, when upregulated, promote C > G and C > T mutations especially in the T C(A|T) context (mutated base in bold; Figure  4a, Table  1) [ 41, 42, 67].

However, significant attention has been placed on off-target mutations especially in the context of human embryos.

Many of the women undergoing this procedure have inherited genetic mutations, especially in the genes BRCA1 or BRCA2.

This highly correlates with p53 mutations, especially in the DNA-binding domain [1].

Together with our report on the saeS mutation in the ausA mutant, these examples clearly show that great care should be taken during genetic manipulation of S. aureus in order to prevent acquisition of secondary mutations, especially in saeRS and agr, and appropriate genetic complementation experiments used.