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The mutation eliminated the dopamine D3 receptor without any detectable changes in both dopamine D1 and D2 receptors.
The other mutation eliminated the flower abscission zone, providing "jointless" fruit stems that reduced fruit dropping and facilitated mechanical harvesting.
Based on our results, this mutation eliminated the repressive effect that miR-20b had on luciferase activity(Fig. 3Bi and Ci).
C97 mutation eliminated the diphenolase activity, but 2 Cu atoms were incorporated.
We found that S184A mutation, but not S347A mutation, eliminated the phosphorylation of ZBTB16 induced by serum starvation condition detected by pan-phospho-Ser antibody.
On the other hand, the RK mutation eliminated the thio-phosphorylation-dependent inhibition of MLCP, suggesting an importance of the basic cluster prior to phospho-Thr696 in the inhibition, in agreement with the autoinhibition model.
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The point mutation eliminates the effect of Kvβ2 on Kv1.2 membrane targeting and axonal targeting via disrupting the Kv1.2-Kvβ2 binding, although the mutant itself is still concentrated in axons [19].
The H64A mutation eliminates the ability to form hydrogen bonds and decreases the side chain size.
The Q302A mutation eliminates the hydrogen bond interaction, generating a network with an interaction energy of 2.0 (Fig. 1E).
Our study confirms other recent reports that NOTCH1 mutation eliminating the PEST domain, has a prognostic value as a novel risk marker in CLL similar to TP53 mutations.
For example, Gly551Asp, the most common class III mutation, eliminates the ability of ATP to increase the opening rate of CFTR [ 11].
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