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In contrast, the ΔN296 mutation effected a marked reduction in microtubule assembly while the N296H mutation also significantly reduced microtubule assembly, but less so ΔN296 [ 12].
To obtain further evidence that the L502A mutation impacted on the ability of SPAK to bind WNK1 and NKCC1, we immunoprecipitated SPAK from kidney, brain and testis, derived from littermate wild-type and SPAKL502A/L502A homozygous animals of 2 months of age and tested how CCT domain mutation effected in association with WNK1 and NKCC1.
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There are notable exceptions to this such as mutations effecting permeability (i.e. efflux pumps and porins), as well as mutations effecting global metabolism such as mutations leading to small colony variants.
Mutated nucleotides are underlined and in bold and the codon of the mutation effects are indicated in bold.
"Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α." Integr Biol (Camb) 5, no.
I had suggested that his term "mutation pressure" would better be called the "probable mutation effect" and would generally interfere with the development of the phenotypica manifestation which it controlled.
The groundwork of this area is based on the hypothesis of a combination of energy absorption, mass deposition, and charge transfer of energetic ions in the organisms, resulting in damage and inducing mutation effects.
The models semiquantitatively reproduce the approximate order of events of unfolding as well as subtle mutation effects and effects resulting from differences in sequences of similar folds.
With similar accuracy, we predict the mutation effects for an 11th protein that was omitted from the initial training and testing of the machine-learning algorithm.
Interactions between the genetic background and experimental manipulations are not predictable and must always be tested in order to reach conclusions whether mutation effects can be generalized.
the mutation effect on phenotypic expression and biodiversity generation (questions 12 and 18); and.
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