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We validated the unique mutation dynamics of minimal introns in keeping their near-optimal size and GC content, and our observations suggest potentially important functions of human minimal introns in transcript processing and gene regulation.
In this study, we report the mutation dynamics of nine VNTR loci used for VTEC O157 subtyping.
Our characterization of the microsatellite threshold based on mutation dynamics of repeats reflects this fundamental property of microsatellite birth in the life cycle.
Conserved microsatellites are a boon for the exploration of the mutation dynamics of microsatellites above the species level, an approach that has been rarely used to date (Zhu et al. 2000; Kelkar et al. 2008).
Similarly, we analysed the mutation dynamics of the recombinant MSV genomes (some of which had evidence of up to 22 recombination breakpoints) isolated from infected maize plants by Monjane et al. [ 47].
To investigate whether there is an association between recombination and increased basal mutation rates or increased degrees of selection favoring the survival of mutations, we compared the mutation dynamics of the MSV-MatA and MSV-VW field isolates of Maize streak virus (MSV; Mastrevirus), with both a laboratory constructed MSV recombinant, and MSV recombinants closely resembling MSV-MatA.
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Accomplishment of "1000 Genome Project" revealed immense amount of information about variation, mutation dynamics, and evolution of the human DNA sequences.
This helps us understand the overall effects of clonal interference and multiple-mutation effects, but still falls well short of a direct and detailed description of mutation dynamics in evolving populations.
In this regard, knowledge of mutation dynamics is particularly necessary in plants, which have been insufficiently explored.
Thus, such models remain crucial tools for checking and expanding upon nonquantitative verbal models of mutation dynamics during invasions.
Future studies will be necessary to evaluate whether serial monitoring of plasma DNA mutation dynamics using both dPCR and/or NGS may facilitate early detection of therapeutic response in ER + MBC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com