Sentence examples for mutation driver from inspiring English sources

Whole exome sequencing places the zinc-finger transcription factor GATA3, with a 10% frequency of alterations, among the top three (together with p53 (TP53) and phosphoinositide-3-kinase (PIK3CA)) mutation driver genes in breast cancer [ 1, 2].

Identifying cancer-associated mutations (driver mutations) is critical for understanding the cellular function of cancer genome that leads to activation of oncogenes or inactivation of tumor suppressor genes.

One example is the discovery of isocitrate dehydrogenase mutations as driver mutations in many different human cancers.

We consider specific situations arising during tumorigenesis, such as the emergence of positively selected mutations ("drivers") and the accumulation of neutral variation ("passengers").

Benchmark complexes: For independent validation, we used manually curated human complexes from CORUM [ 27], a total of 1843 complexes of which we used 722 having size at least 4. Benchmark genes and TFs in cancer: For validation we used known (mutation-driver) genes (total 118) from COSMIC [ 28] and known TFs (total 82) in cancer from [ 29].

The model assumes all mutations (drivers and passengers) are initially selectively neutral and arise as replication errors.

High-throughput prioritization of cancer-causing mutations (drivers) is a key challenge of cancer genome projects, due to the number of somatic variants detected in tumors.

Transcriptome data, measures of genomic instability, mutation within driver genes, cellular transformation and other endpoints are being collected.

About 22% of the second mutations in doublets are expected to be silent if they are "passenger" mutations, rather than "driver" mutations [25].

Note that here we implicitly assume that all non-synonymous mutations in driver genes are potential driver mutations if they are selected by a method.

The research looked at mutations known as driver mutations, which spur cancer growth.