Sentence examples for mutation directly from inspiring English sources

The method provides a convenient and simple strategy to detect point mutation directly in human genome.

Similarly, work from our lab demonstrated that IDH1 mutation directly causes the G-CIMP phenotype, reduces global 5-hmC through TET2 inhibition, results in hypermethylation of the repressive histone marks H3K9 and H3K27, and blocks differentiation (Turcan et al., 2012).

We speculate that the phosphorylation of FUNDC1 Ser13 may generate steric hindrance for LC3B binding, while the LC3B R10A mutation directly destroys the interaction between Arg10 of LC3B and Ser13 or nearby Asp14 of FUNDC1 peptide, leading to the decreased binding affinity.

Researchers are trying to introduce the rare mutation directly to patients using gene therapy, though more research is needed before clinical trials can begin.

The ΔF508 mutation directly affected the isolated NBD1 domain.

Is this malignant myosin mutation directly disrupting myofibril assembly through molecular level changes, or is this disarray a secondary effect of changes in global cardiac function and loading?

Thus far, oncogenic viruses have not been shown to induce DNA mutations directly in human cells; rather, their contribution seems to lie in promoting and hastening the process of mutation.

Several genetic mutations directly affect the binding of hormones to their NHRs and result in genetic diseases.

We utilized CRISPR/Cas9, which can be designed to target a specific genomic locus, to introduce site-directed point mutations directly into the T. gondii genomes.

We generated live attenuated human influenza A vaccines (LAIVs) by rationally engineering mutations directly into the genome of a pandemic-H1N1 virus.

The duplex PCR products of the sample with known Constand spring mutation (CS /αα, Quonsze mutation (QS /αα, and Weastmead mutation (WS /αα DNA showed significantly different profiles, which suggests that DHPLC analysis at 63.8°C can detect potential mutations directly.