Sentence examples for mutation detection has from inspiring English sources

Besides the diagnostic value, gene mutation detection has therapeutic and prognostic implications through the need to adjust the dose and the duration of oral anticoagulation.

The problem with these studies is that there is inherent bias because most mutation detection has to be performed on DNA from blood, and the woman with breast cancer therefore have to be alive to be tested.

Both data illustrate that p53 mutation detection has limited clinical utility for the detection of bladder tumours, but that voided urine specimens provide a good material for studying p53 in a prognostic attempt.

A popular and low cost method of mutation detection has been the protein truncation test (PTT), where target regions of BRCA1/2 are PCR amplified, transcribed/translated in a cell-free protein synthesis system and analyzed for truncated polypeptides by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and autoradiography.

Resequencing array-based mutation detection has been reported to produce a throughput of nearly 100 patients per technician per month and can thus be used as a method for initial genetic screening while being supplemented with conventional dideoxy sequencing for samples in which the array cannot identify a causative mutation [ 13].

Consequently, methods for somatic mutation detection have to be able to detect DNA changes that may be present in a low proportion of the total DNA isolated from the sample.

A rapid and reliable mutation detection assay has been developed.

Oligonucleotide-gated mesoporous nanoparticles-based analysis is a new platform for mutation detection that has the advantages of sensitivity, rapidity, accuracy, and convenience.

A novel PCR-based mutation detection method has been developed by Transgenomic.

By comparing with the previous TILLING by sequencing study [ 17], our mutation detection method has several differences.

Additionally, the turn-around-time for the entire specimen processing and mutation detection platform has to be quick, in order to integrate into the rapid pace of clinical decision making and impact patient management.