Sentence examples for mutation detection for from inspiring English sources

On the other hand, the mismatches between the target- and probe-DNA caused a significant reduction of electrochemical response, in which was correlated with the amount of mismatched base pairs, therefore the current DNA biosensor had potential applications not only in DNA quantification but also in mutation detection for clinical diagnostics and laboratory applications.

The time scale of mutation detection for Mendelian traits in non-laboratory animals is shown in Fig. 1.

Mutation detection for germline BRCA1 and BRCA2 mutations was conducted by using direct DNA sequencing and multiple ligation-dependent probe amplification (MLPA), as previously described [ 12, 13].

Given the potential impact of KRAS mutation detection for CRC prediction and prognosis, a reliable diagnostic test may affect future therapeutic decision making.

Consistent with those results, we found that use of a smaller amplicon increased the sensitivity of mutation detection for KRAS mutations in the cell lines tested.

Original research articles that evaluated the diagnostic accuracy of K-ras mutation detection for the diagnosis of PC in at least 30 patients were included.

The next generation sequencing approach offers several advantages over the traditional methods, including the ability to simultaneously sequence hundreds of genes in a single test, have a higher depth of coverage and thereby heightened sensitivity for mutation detection, ideal for 'precision medicine'.

Mutant DNA was amplified by PCR and sequenced in both directions, as recommended by Stratagene for the λ Select-cII™ mutation detection system for Big Blue® rodents (Stratagene, CA, USA).

The mutation detection rate for the current NGS approach was 87.5% for the 12 RD patients with 24 known mutations (21/24 = 87.5%).

Analysis of the ability of this microarray to detect known gene mutations has shown a 97% mutation detection rate for base substitutions.

In fact, the overall mutation detection rate for many IRD-associated genes is very low, except for conditions such as Stargardt disease and achromatopsia where disease-specific panels are successfully utilized due to the limited number of genes involved.