Sentence examples for mutation destabilizes an from inspiring English sources
Oncogenic IDH1R132H mutation destabilizes an IDH1 "regulatory segment," which otherwise restricts compound access to the allosteric pocket.
This mutation destabilizes a disordered binding site embedded in a longer disordered (fuzzy) segment in the tooth of the Head.
The 10 + 16 mutation destabilizes a stem loop structure in intron 10 leading to a 2 6-fold increase of exon 10-containing mRNA in patients (15, 16).
Excess E10 inclusion in FTDP-17 can be caused by intronic mutations destabilizing a stem-loop protecting the 5′ splice site at the E10/intron 10 junction.
Mutation destabilizes the mutated MPV17 transcript in the lymphocytes and prevents its translation in the transfected cells.
This mutation destabilizes h1 and favors formation of an alternate stem-loop structure within the leader sequence of the pre-cleavage 17S rRNA, thus disrupting formation of h2.
The G229S mutation destabilizes the binding of Ero1 to a flavin cofactor at the restrictive temperature, which likely impairs its ability to oxidize PDI (Gross et al. 2004).
The p.Trp690Ser substitution (c.2059G>C), a known XP mutation, destabilizes XPC and causes functional defects, including severely impaired repair of 6-4 photoproducts and lack of XPC binding to undamaged or damaged DNA (5, 29).
This value represents the change in free energy of the alanine mutation, so a larger, more positive value indicates that the alanine mutation destabilizes the complex and the original residue is a hot spot.
Comparing the structures of GDP bound wild-type StNFeoB and an A143S mutant protein (equivalent to EcNFeoB S150), illustrated that the mutation destabilizes the nucleotide base by altering the hydrogen-bonding network.
These results are consistent with the hypothesis that the mutation destabilizes the protein [35]; however, whether the mutation leads to degradation of the protein (as typically happens with temperature-sensitive proteins) or only inactivation remains to be determined.
