Sentence examples for mutation demonstrated increased from inspiring English sources

The R840C mutation demonstrated increased NC-TDI's with all ligands and concentrations tested compared to wild type.

Similarly, the xprG1 gain-of-function mutation demonstrated increased protease activity CI,1.28).

Thus, despite the absence of premature senescence, ECs bearing HGPS or WS-associated mutations demonstrated increased susceptibility to apoptosis.

Tumour cells with these mutations demonstrate increased sensitivity to cisplatin and poly (ADP-ribose) polymerase (PARP) inhibitors.

In contrast, a similar study of 221 Korean familial breast cancer patients [ 44] identified 81 deleterious mutation carriers, and demonstrated increased TN phenotype for BRCA1 mutation carriers (P <0.00001,57%, n = 35), but not BRCA2 mutation carriers (P =0.9, 13.9%, n = 36) compared with non-carriers (13%, n = 130).

This contrasts with the findings in the symptomatic mutation carriers, who demonstrated increased mean diffusivity in all the subcortical grey matter structures assessed; the pattern of change in diffusivity that is more typically observed in neurodegenerative disease.

In addition, patients harboring mutations in succinate dehydrogenase demonstrated increased HIF-1 α levels.

Bull et al. have demonstrated increased frequency of p53 mutations in carcinomas with neu/erbB2 amplifications [ 51].

Clinical studies of women with BRCA1 mutations treated with radiation for breast cancer have not demonstrated increased acute or late toxicity (Pierce, 2005).

Gefitinib-resistant subpopulations demonstrated increased Akt phosphorylation (not inhibited by gefitinib), reduced PTEN protein expression and loss of the EGFR gene mutation when compared with parental cell lines.

In line with our findings, C. elegans hermaphrodites that are long-lived due to p53 (cep-1) mutation did not demonstrate increased resistance to oxidative (or UV) stress [ 16], however resistance to gamma irradiation was not examined.