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If a mutation created a salmonella strain that always opted out of the suicide attacks, these salmonella would benefit in the short term within the gut, but they would have trouble spreading to the next victim.
This point mutation created a version of Chs2 that cannot be phosphorylated on S222.
This mutation created a nonsense mutation in the gene for the chloride channel protein, skeletal muscle (Clcn1).
One study has shown that even a BRCA1-BRCT missense mutation created a conformational change and functional instability in BRCA1 protein [ 27].
In addition, the mutation created a greater conformational change in ZnF1 than in ZnF2, probably because Arg-299 is located near the zinc ion of ZnF1.
To permit rapid identification of the K-Ras codon 117 mutation, a PCR RFLP assay was designed where the presence of the mutation created a recognition site for the restriction enzyme Bsr S1.
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In cases where the mutation created an AfeI site (pHK3, pHK5 27, pHK51) plasmids were digested using BsrGI and integrated at the RIF2 locus in OAy1002.
Oxygen transport via the Xe1 cavity was attenuated, and the Val97 mutation created an additional docking site for the oxygen molecule by expanding the size of the Xe2 cavity.
This mutation creates a new chromosome, sometimes extremely different from its parents, but anyway useful for the renewal of the population.
The researchers believe the pepper's capsaicin-creating gene appeared after five mutations occurred during DNA replication, with the final mutation creating a functional copy.
That apparently happened, Kinzler says, because the mutation creates a stretch of eight consecutive As, which can throw off the enzyme that transcribes the DNA and completely garble the resulting protein.
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