Sentence examples for mutation coupled with from inspiring English sources
Research on the evolutionary genetics of this disease suggests that there are two main reasons for the persistence of Huntington's in human populations: mutation coupled with weak selection.
Due to the complexity and rate of parasite mutation coupled with regional variations, and the emergence of P. falciparum strains which are resistant to antimalarial agents such as chloroquine and sulfadoxine/pyrimethamine, there is constant pressure to find new and lasting chemotherapeutic drug therapies.
Additionally, stabilization of alternative states by mutation, coupled with ensemble-based analyses, may allow for more detailed dissection of multiple ncRNA tertiary conformations and their functions.
A single case of missense mutation coupled with the loss of the other allele has also been reported for a gastric and colorectal tumour sample [ 18].
Thus, oncogenesis can be viewed as an evolutionary process associated with multiple rounds of mutation, coupled with selection for specific 'attributes'attributes
Therefore, the ACC presented a bi-allelic inactivation of the BRCA1 gene due to the constitutional mutation coupled with the somatic loss of the wild-type allele.
The additional observation that various phenotypes must be acquired suggests multiple mutations with no clonal expansion or a mutator mutation (a mutation that generates more mutations) coupled with clonal expansion [ 41].
Analysis of the aberrant activation of the MAPK signaling pathway in a subset of melanomas with BRAF mutations coupled with the development of selective RAF inhibitors that target mutated BRAF protein has revolutionized therapy for patients with advanced-stage disease.
He believes in Darwinian evolution, of course, and the premise that life evolves through genetic mutations coupled with the crucible of natural selection.
Two theories have been proposed to explain this association including (1) solar-induced mutations coupled with immunosuppression reduces tumour surveillance [37] and (2) metabolites from certain IS agents such as AZA appear phototoxic and thus increase the skin's sensitivity to ultraviolet light damage [38].
A number of mechanisms have been suggested to be responsible for generating diversity at MHC loci, including accumulation of point mutations coupled with recombination between alleles and loci [5].
