Sentence examples for mutation could reduce from inspiring English sources

The YG mutation could reduce BACE and lysosomal degradation of APP, if mutant APP has impaired endocytosis [both processes are largely dependent of APP endocytosis [22], [23], [24]).

The presence of one particularly harmful mutation could reduce the potential role of the second variant.

The L164P mutation could reduce the intrinsic activity of the Gpd1 enzyme or its expression by lowering GPD1 mRNA stability.

It is possible that charge is also important for interaction of the OB-fold with the Trt1 complex, and alteration of this charge, for example through the K75A mutation, could reduce telomerase activity.

Comparison of the de novo maturation rates in various GFP variants revealed that some folding mutations near the chromophore promoted rapid chromophore maturation and that the accumulation of mutations could reduce the maturation rate.

Thus, HSPB1 mutations could reduce neuronal maintenance by contributing to global transport defects affecting the MT network directly and indirectly, through deregulation of the level of phospho-NFs.

Given that several signalling pathways, such as Hedgehog signalling, depend on cilia, this provides another route by which MGS mutations could reduce cellular proliferation rates without contributing to genetic instability.

Besides, the fact that viral loads are higher among children than in adults, can lead to the development of resistance mutations which could reduce the effectiveness of antiretroviral drugs in further combinations.

Additionally, by finding an optimal mutation rate, we could reduce the computation time (number of generations) needed to arrive at a given quality of solution or alternatively increase the quality of solution for a given time of computation.

Previous studies demonstrated that Erv41p-Erv46p complex interacts with glucosidase II and modulates glucosidase I activity, as well as cells lacking a cycling Erv41p-Erv46p complex display a mild glycoprotein processing defect [ 26], and the mutation of ERGIC3 could reduce the transport between the ER and the Golgi apparatus [ 29].

CYP1A2*1C (−2964G>A) and CYP1A2*1F (734C>areare common allelic variants in Chinese population, and the effect of the two mutations on CYP1A2 activity is opposite: mutation of CYP1A2*1C (−2964G>A) could reduce the CYP1A2 enzyme activity induced by smoking, while mutation of CYP1A2*1F (734couldcould strengthen the induction of smoking on the enzyme activity.