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How the L63V mutation could produce a hyperactive DDR2 is not clear; conceivably, the mutation could destabilise an autoinhibited form of the receptor.
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Characterization and structural analysis demonstrated that these mutations could produce cumulative or synergistic improvements in thermostability or catalytic efficiency of phytase.
If genetic mutations could produce brains that were smaller and more efficient but still worked well enough to master the skills of survival, it makes sense that those who had them would live longer in the times of scarcity and famine characteristic of our not-so-distant past.
Altering the metabolism of a few attractive and pathogenic bacterial strains by changing culture conditions or introducing a library of mutations could produce this evidence.
39 Our estimate of 44% suggests that on average for each codon position up to 28 different mutations could produce viable DENV-2 mutants (codon mutability).
An X value of −1 was given if the student explicitly denied that mutations could produce new functions (a very rare response).
When the same strain is introduced in both species and ϕ = 0, a medium or high number of mutations could produce ranging from 0 to 9% when using 10 VNTRs (Fig. 1C).
The analysis revealed a very small target-based resistance spectrum, as only a very few mutations could produce RNAPs that are both resistant to GE and still catalytically active.
On the other hand, the influence of ESSs on cryptic 5′ss and their interplay with mutations could produce aberrant mRNA patterns (5, 11– 13) through poorly explored combinations of mechanisms, the definition of which would in turn help implementing our knowledge of ESS physiological functions.
Although other genes present in the same deleted region could account for the phenotype, this case report suggests the possibility that the heterozygosis for DG-null mutations (haploinsufficiency) could produce pathological consequences in humans.
To allow quick analysis of future mutations that could produce drug or vaccine-resistant strains, we provide a tool for 3D visualization of the neuraminidase structure models with mapping of drug and antibody recognition sites on the supplementary webpage.
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