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Most people who had come down with swine flu in the spring had survived; a mutation could mean that the death rate would be much higher when the virus returned in full force in the fall.
Secondly, the loss of affinity upon a mutation could mean that a particular residue is involved in interactions with the ligand in the final binding pose, but it cannot be excluded that such a residue only takes part in the process of ligand entrance or induced-fit.
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Some studies suggest a link between activity and annual average metabolic rate, which could mean fewer mutations in languid species.
Paralogs have been cited as capable to partially compensate for the loss of gene function [ 42, 43], so the greater frequency of paralogs could mean that mutations are less likely to have a critical impact on phenotype.
The reason for this is unknown; however, it could mean that the mutation affects the interaction between PREs.
The patchwork patterns of somatic mutations that Evrony and colleagues uncovered could mean that rare, as-yet unrecognized brain disorders may exist.
This could mean that such mutations do not have any important phenotypic consequences, or, alternatively, that they are lethal.
The fact that all of these possible Syndrome X cases are girls is intriguing – it could mean that the crucial mutation is on their X chromosome.
Could mean.
That could mean anything.
Exposure could mean death.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com