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Exact(6)
As expected, the I657V mutation could increase the antigenic propensity of the NWFNITNW region because of the elevated hydrophilicity, flexibility and turns (Fig. 5).
Thus, it is plausible that the I638F mutation could increase the basal activity of DDR2.
Page 6 introduces the hypermorphic class of mutation/allele and asks how a mutation could increase activity.
For instance, the dectin-1 single nucleotide polymorphism (SNP) Y238X mutation could increase the likelihood of Candida colonization and indirectly associate with GVHD [ 49].
Our results show that mitND6 gene nonsense and missense mutation could increase the expression level of phosphate AKT and ERK1/ERK2, but had no effect on total AKT and ERK1/ERK2.
Wang et al., in another work, showed that IDH1-R132H mutation could be predictive of response to radiation therapy; indeed, they suggested that IDH mutation could increase radiosensitivity in hypoxic conditions, underlining the primordial IDH mutation determination whatever the diagnostic approach.
Similar(54)
Alternatively, the Spy mutations could increase chaperone efficacy in other less direct ways.
Again these mutations could increase the activity or maintaining the activity at higher temperatures.
For example, modifying the cargo to enable only truncating mutations could increase the likelihood of identifying tumour suppressor genes [248].
For example, transcription-related mutations could increase synonymous substitution rates in coding regions over and above GC effects.
Simple calculations suggest that, in a species with a large effective population size similar to Z. mays, even weakly beneficial mutations could increase to high frequency in timescales similar to the divergence between luxurians and Z. mays (Chevin and Hospital 2008).
More suggestions(15)
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