It thus stands to reason that HER3 expression patterns and mutation status could impact the efficacy of therapies based on EGFR inhibition.
Our results include confirmatory findings such as the V210I mutation, and new findings including P137M, G142D, G142N, D144P, K185T, V189I, H187Y and T191P mutations, which could impact structural stability.
The conclusion of the paper is highly interesting: that RNA chaperones may buffer mutations that could impact on mRNA folding.
The pattern of NBDM has the potential to alter on a genome-wide scale not only the deleteriousness of germline mutation but also, and perhaps even more importantly, that of somatic mutation, and therefore it could impact fitness by affecting not only the genetic quality of one's progeny but also, and perhaps mainly, individual viability.
This helix contains a crucial amino acid (K940) involved in proton transport (Su et al., 2006) and a mutation in this helix could impact the rotational movements leading to compound export.
Because we utilize the fraction of segregating sites in a region as well as their allele frequencies, variation in the spontaneous mutation rate across the genome could impact predictions.
It is possible that OAF1 mutations triggered variation of cell surface hydrophobicity that could impact flocculation [ 42].
Thus, these mutations could directly impact signalling, similar as in AD, which may contribute to neuronal degeneration.
Although further work is needed in this area, it is tempting to speculate that CHCHD10 mutations could negatively impact upon PCD resulting in an impaired ability to eliminate dysfunctional neurons, which in turn perpetuate a negative spiral of cell degeneration via caspase‐independent mechanisms.
In addition, loss of STIM2 affected the ability of T cells to maintain NFAT concentrations in the nucleus, implicating that even STIM2 mutations could potentially impact transcriptional processes in cytotoxic T cells that are important for their activity against tumour cells (Oh-Hora et al, 2008).
