Depending on the quality and quantity of alterations in the amino acid sequence, exchange of partly homologous DNA and mutations could generate minor or major changes in the FucT activity of the isolates, and thus affect the presentation of surface molecules to the bacterial environment.
On the other hand, reduced MHC genotype diversity in gynogenetic triploids is probably due to the lack of recombination and segregation in these asexually reproducing organisms, where only point mutations could generate new MHC alleles.
Sequencing errors, problems with annotation, alternative splicing, amino acid repeats, and frameshift mutations could generate a higher rate of false positive with the branch-site model (Mallick et al. 2009; Schneider et al. 2009; Markova-Raina and Petrov 2011), therefore, generating accurate alignments is an essential step in the inference of positive selection.
At this stage of the experimentation, establishment of clones with perfect (100%) identity, were very encouraging for us to rule out mutations which could generate aberrant proteins.
A rapidly determined patient-specific tumour mutation pattern combined with a flexible mutation-targeting drug platform could generate a mutation-targeting individualised therapy, which would benefit each single patient.
To determine whether other mutations in ER could generate phenotypes like those of jba-1D/+er-20 plants, we analyzed the genetic interactions between jba-1D/+ and either the L er accession or the Col accession carrying the er-2 allele.
Therefore, long-term evolutionary forces such as genetic drift or mutation could not generate autosomal genetic difference between sexes [ 29].
The second objective was to study evolutionary processes (recombination, mutation, migration and selection) which could generate or maintain variation in CHV1 occurring in Europe.
This rate is equivalent to 2 × 10−8 mutations/nucleotide/generation if mutations at 1,000 nucleotides could generate haemophilia.
On the other hand, the low-DNA template input in PCR could generate false mutations.
