Sentence examples for mutation could disrupt from inspiring English sources

This creates a more complex environment for neurogenesis and neuronal migration, adding new arenas in which neurodevelopmental disease gene mutation could disrupt corticogenesis.

This would explain why a single Cys mutation could disrupt the assembly of the multiprotein complex thereby, obliterating secretion.

The MAPP scores for this mutation are uniformly high at all phylogenetic depths examined, suggesting that such a mutation could disrupt some long-conserved function of the protein.

Although L95 does not make direct contact with Cul3 and is mostly buried within the BTB domain, this residue is in close proximity of the Cul3 chain, and replacement of an aliphatic residue with a large aromatic residue at this position would probably affect the conformation of the BTB domain, suggesting that the p.L95F mutation could disrupt the KLHL9/Cul3 complex.

We next analysed if the point mutations could disrupt the self-oligomerization pattern of M1.

These mutations could disrupt the binding sites for MAPs, leading to altered function or possibly dominant-negative effects.

Based on our structural modelling and simulations, the altered conformation and increased flexibility through the G583R mutation could potentially disrupt protein interactions.

This leads to the prediction that mutations in this region could disrupt association.

These two genes play a major role in regulating cell traffic, endocytosis and exocytosis (39, 40), and mutations in these genes could disrupt the polarity of RPE and function leading to retinal (photoreceptor) degeneration.

This binding is likely conserved in C. elegans as this side-chain hydroxyl and the RPB-5 arginine residues are conserved (RPB-5 R10 and R13 in C. elegans), and mutation of this amino acid could disrupt RPB-1/ 5 interactions.

We next tested whether the AMPH2 mutations found in ARCNM patients could disrupt the interaction of amph2 with N-WASP.