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Scientists are trying to understand how a virus can be wildly contagious among birds but almost impossible to spread in mammals -- and what type of mutation could change that.
We were interested to know if and if yes, to what extent a single mutation could change both morphotype and biological fitness of P. aeruginosa in the atypical niche of mammalian lungs.
Although the overall drug accumulation of at least phenanthridines was unaffected, a potentially lower Δψm in cells expressing the L262P or A281del mutation could change the intracellular drug distribution.
Although low levels (<20%) are unlikely to cause disease in the immediate offspring, the amount of the pathogenic mtDNA mutation could change on future transmission down the female line, limiting the effectiveness of the treatment in the longer term.
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New mutations could change pleiotropic influence on the genetic system, even in somatic tissues.
The mutations could change the brain's structure, number of neurons, or the strengths of the connections between those neurons.
Further analyses of the mutant MCPH1 proteins indicated that most of the human-specific mutations could change the regulatory effects on the down-stream genes.
Because the inserted DNA could be modified in advance, say, by disabling it with a mutation, scientists could change specific genes at will.
(2006) synthesized E. coli with each possible combination of amino acids at the three sites that needed to be changed and showed that there were indeed sequences of mutations that could change TEM-1 to TEM-52, while increasing antibiotic resistance in each step.
Thus, a Sox10 mutation in ASCD could change coat colour, possibly cause white speckling and deafness through a lack of melanocyte function in the inner ear and altered neural crest development.
AceF is a subunit of pyruvate dehydrogenase so mutations in aceF could change central metabolism; aceF mutants can for example have elevated pyruvate levels in cells (Tomar et al. 2003).
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CEO of Professional Science Editing for Scientists @ prosciediting.com