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How this mutation could alter the lectin site at such a distance is therefore unclear.
The mutation could alter physiological functions of tumor- and apoptosis-associated genes.
However, it is not clear how this mutation could alter the binding of ΔNp63 α in a promoter-specific manner.
The finding of a germline deleterious mutation could alter treatment decisions; for instance, women with germline mutations might opt for more radical surgery or may consider prophylactic surgery to the contralateral breast or ovaries.
We tested whether a reduction of the efflux components in STM 2683 through cadA mutation could alter the regulation of znuC upon exposure to Zn/Cd or to various mixes of the two metals.
The Q950H mutation could alter responses mediated by the MR during the evolution of Old World primates about 35 million years ago, when they and New World monkeys separated from a common ancestor [ 17].
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Site-directed mutagenesis of a thermophilic xylanase from Caldicellulosiruptor bescii revealed that four out of five mutations could alter the enzymatic pH optima toward acidic condition without compromising the catalytic activity and thermostability.
Within just 5 h, we successfully determined the electricity generation capacity of two known bacterial electrogens (wild-type S. oneidensis and P. aeruginosa) and another metabolically more voracious organism with 4 isogenic mutants constructed with the hypothesis that such mutations could alter their electrogenic properties.
Thus, oncogenic mutations could alter the activity of c-Myb, a transcription factor that is normally regulated during the cell cycle.
We hypothesized that CN mutations in the SELENBP1 locus could associate with the disorder and that these mutations could alter the gene product's activity in patients.
Furthermore, it is hypothesized that TRPC6 mutations could alter the intracellular milieu, which, as a consequence, would induce an irreversible cell state.
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