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Fig. 3 B is the contour map of position mutation correlation matrix R(mut)L×L.

Then the position conservation correlation matrix and position mutation correlation matrix is constructed from the amino acid position mutative equation.

The position mutation correlation matrix R(mut)L×L of PDZ is graphically shown in Fig. 3.

Fig. 3 A is the relief map of position mutation correlation matrix R(mut)L×L of PDZ database.

Before computing the amino acid position mutation correlation matrix, we have to build the amino acid position mutative equation, which measures the mutation of amino acid k at position l in protein family.

Table 1 lists 24 position pairs with higher correlation coefficients (r(mut)i,j>0.80) in the mutation correlation matrix R(mut)L×L, which distribute in 12 red regions in Fig. 3 B.

For each downsampled dataset, the cell-to-cell correlation matrix is calculated and correlated with the cell-to-cell correlation matrix for the 2,511-gene 2,511-gene

10 by 10 correlation matrix.

Wei corrplot: visualization of a correlation matrix.

Correlation matrix shows clusters of synchronous activity.

A correlation matrix uniquely may define a weighted network.