Sentence examples for mutation cooperates with from inspiring English sources

Therefore, in this instance, Fgfr3 mutation cooperates with β-catenin activation to drive lung tumorigenesis.

It was also shown that, in zebrafish, a hypomorphic mitfa mutation cooperates with oncogenic BRAF to promote superficial spreading melanoma (Lister et al., 2014).

We demonstrate here that activating mutations of FGFR3 are unlikely to be the sole initiating factor for UCC and that neither β-catenin exon3/+ nor K-Ras G12D/+ mutation cooperates with FGFR3 to drive UCC.

By contrast, no papilloma was observed in the UroIICre + K-Ras G12D/+ cohort aged up to 18 months (n=20), indicating that Fgfr3 mutation cooperates with K-Ras mutation to drive papilloma formation.

Recent studies from our laboratory demonstrated that APC is required for maintaining epithelial homeostasis in the mouse mammary gland and its mutation cooperates with other oncogenic alterations, such as overexpression of the Polyoma Middle T antigen (PyMT) oncogene [ 5, 6], to enhance primary mammary tumorigenesis.

Therefore, given the observation that Ras mutation is inefficient at driving bladder carcinogenesis alone in the mouse, the aim of this study was to test whether Ras overexpression or mutation cooperates with deregulated Wnt signalling to promote UCC in the murine urothelium.

Taken together, we conclude that nf1a and nf1b mutations cooperate with p53 loss to generate high-grade gliomas and MPNSTs.

It is interesting to note that both Dap and Cic act on Cyclin E/CDK2 and that their mutations cooperate with rbf1 mutations to cause uncontrolled proliferation.

It remains possible that one or more of these unidentified MMTV-induced mutations cooperated with the Int6 truncation to produce the observed hyperplastic alveolar nodules and tumors.

It is becoming increasingly clear that RUNX1 mutations, cooperating with other various gene abnormalities, may promote the development of MDS/AML.

These theories are differentiation-maturation mutations cooperating with proliferation/survival mutations, lineage-addiction or -dependency models, and the existence of "cancer stem cells" arising from an ordered sequence of phenotypically distinct stem-cell and intermediate-precursor populations [ 62- 64].