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The ein2 mutation conveys a systemic ethylene resistance through the elimination of a signalling relay step between the cytoplasm and the nucleus [45].
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The first theory states that activation or inactivation of a gene or a set of genes by specific mutations conveys a selective advantage to a cell resulting in clonal expansion of cells harbouring these mutations.
No deleterious ASXL3 mutation was found in a small cohort of patients with BOS without causative ASXL1 mutation (Hoischen, personal communication), consistent with ASXL3 mutations conveying a phenotype distinct from BOS.
Extended families with multiple cases are a proven means of discovering genes that when mutated convey a high risk of disease [ 25], and are an efficient sampling design for identifying mutation carriers for studies of genetic and environmental risk modifiers.
No one disputes the use of these procedures for those with either a BRCA1 or BRCA2 mutation, which convey a lifetime risk of developing breast cancer as high as 85percentt.
Myriad, which licensed the BRCA genes from the University of Utah and others who discovered them, runs a testing service to check for mutations that convey a risk for breast cancer.
Therefore, the fate of the duplicated TFIIAγ genes can be alternatively explained by the Dykhuizen-Hartl effect [ 31, 34], which predicts that one of duplicate genes evolves under relaxed purifying selection and the fixed mutations later convey a selective advantage in a novel environment or genetic background.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com