Sentence examples for mutation converting the from inspiring English sources

Then, if a deletion of the intervening sequence between the two copies occurs followed by a mutation converting the stop codon of the first copy into a sense codon (Fig. 7), this results in the elongation by fusion of the ancestral gene and its copy.

Interestingly, the mutation converting the CTC triplet to ATA in w3mut and abrogating ZAM-IN binding is encompassed within this homologous site (see Fig. 4A and C).

We note also that tti2 -F328S does not suppress a mutation converting the terminal tryptophan of Mec1 to alanine.

Any mutation present in the ancestor that is not identified in an MA line is a false negative, assuming the probability that a mutation converting the ancestor base back to the reference base at any of these sites is negligible.

To address whether the ZEN method can generate mice with precise genome modifications, we coelectroporated Cas9 mRNA, sgRNA targeting Tet2, and a 126-nt donor oligonucleotide with DNA sequence flanking the target site and a 2-nt mutation converting the naturally occurring EcoRV site (GATATC) in the target sequence to an EcoRI site (GAATTC) and recovered live mice.

This mutation converts the termination codon of the ATPase 6 subunit into a glutamine codon, and extends the subunit by ten amino acids (Gln-Trp-Pro-Thr-Asn-His-Met-Pro-Ile-Met) at the carboxyl-terminus.

An in silico analysis of protein folding suggests that neither the S2A and D6A mutation converted the flexible linker of the Cy element region, bordered by S14 and D25, to a more rigid helical fold as observed in the other noncomplementing mutants.

While parental H5 HA exhibited limited binding to human tracheal epithelium, introduction of selected mutations converted the binding profile to that of a current human influenza strain HA.

Ki-ras mutations are found in approximately 90% of pancreatic adenocarcinomas and 40% of colorectal adenocarcinomas (Bos et al, 1987; Almoguera et al, 1988; Bos, 1989) These mutations convert the ras protein to a constitutively active protein, resulting in stimulation of cell proliferation.

In Drosophila the pygoF107 allele, with a single missense mutation converting amino acid 802 in the PHD domain from cysteine to tyrosine, loses Wnt signaling function in both embryogenesis and imaginal disc development [ 8].

However, the D320K mutation converting aspartic acid 320 into lysine (Nrp1 D320K ) successfully abolished VEGF-NRP1 binding while conserving AP-SEMA3A binding as demonstrated through alkaline phosphatase histochemical staining on transfected COS-1 cells.