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Several lines of evidence support that USP8 mutation contributes to ACTH hyperproduction: (1) USP8-mutated PAs expressed higher level of POMC mRNA, (2) patients with USP8-mutated PAs had similar levels of plasma ACTH, although PAs were markedly smaller in size, and (3) USP8 knockdown attenuated ACTH secretion in primary USP8-mutated tumor cells.
How the mutation contributes to Crohn's disease is unclear.
A single amino acid mutation contributes to adaptive color pattern in beach mice.
Perhaps we need to consider the possibility, then, that the BRCA2 mutation contributes to the phenotype in this FA-B case.
Studies suggest that IDH mutation contributes to tumor pathogenesis through mechanisms that are mediated by the neomorphic metabolite of the mutant IDH1 enzyme, 2-hydroxyglutarate (2-HG).
Therefore, these results suggested that although the Rag2-R229Q mutaffectsffecTs T cell differentiation in periphery, the extent to which the mutation contributes to T cell activation was not as severe as previously reported from Rag2 KI/EGFP mice13.
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It can be applied to sequential data prediction in transportation disruption or mutation, contributing to the prediction of transportation disruption.
156– 158 Yet, similar to Bmp4 in finches, the regulatory mutation contributing to differences in expression remained unknown until recently.
It showed that both, mosquitoes with and without the L1014S kdr mutation, contribute to the malaria transmission.
6.5 % were overly reassuring and 0.6 % would have said a BRCA2 mutation contributed to causing the breast cancer.
Insect fitness experiments revealed that the physiological consequences of fou2 mutation contributed to more effective protection against B. brassicae.
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