Sentence examples for mutation contributed significantly from inspiring English sources
Stepwise mutation contributed significantly to genetic differentiation.
Our findings provide no evidence that p16 INK4A)/p14(and) and p53 mutations contribute significantly to familial glioma.
This suggests that new interactions produced by random mutations contribute significantly to the whole PIN topology.
APC mutations contribute significantly to colon carcinogenesis [34] but also have been implied in ovarian cancer development [35], [36].
Therefore, it is likely that fine-tuning of the active site by these remote mutations contributes significantly to the activity changes.
Epigenetic changes and genetic mutations contribute significantly to the onset of human malignancies (Jones and Baylin, 2002; Feinberg et al, 2006).
It is unclear in this point what fraction of the >2000 reported mouse QTL are caused by overt coding sequence mutations, and it is likely that functional non-coding mutations contribute significantly to these traits.
Epigenetic silencing of the O-methylguanine-DNA methyltransferase (MGMT) has been associated with longer survival in GBM patients treated with TMZ, but nuclear factor κB (NF- κB -mediated survival signaling and TP53 mutations contribute significantly to TMZ resistance.
In contrast to the very small impact seen in response to varying the deleterious mutation effects, the beneficial mutation effects contributed significantly to the optimum mutation rate.
Consequently, even if somatic mutations (as reflected in MMR-proficient mutations) would contribute significantly to MMR-deficient mutation patterns, they would not display extensive similarity to germline variation patterns and could therefore not be responsible for the patterns observed in MMR - deficient tumors.
Although the low levels of the T315I mutation in patient 6 are unlikely to have contributed significantly to in vitro resistance, this patient also tested 100% positive for the F317l mutation, another highly imatinib-resistant mutation, suggesting the PBOX compounds also successfully induce apoptosis in cells harbouring this mutation.
