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The Arabidopsis gai mutation confers dominant, GA-insensitive dwarfism [ 7, 8].
The CAG repeat specifies glutamine, and the expanded polyQ domain mutation confers dominant toxicity on the protein.
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Certain APC mutations confer dominant-negative effects with up-regulation of Tcf-B-catenin-mediated transcription in experimental systems [ 26].
The dbf4-ΔN221 dbf4-ΔN221onfers a domutationheconfers bypass.
C61S mutation confers resistance to ISO as well (Grzegorzewicz et al., 2012).
2. A single polar residue at β37 but not at β9 confers dominant protection.
Notably, this same mutation confers nearly complete immunity to HIV.
This mutation confers co-resistance to INH and ethionamide [ 24].
These mutations may confer dominant-negative or gain-of-function properties to p53.
These results indicate that the Sec61α mutants assemble into functional translocons and that the M136T and R66I mutations are sufficient to confer dominant resistance to CT8.
The dominant chr02 selection valley indicates that both AS-15MF and AS-30CQ bear a mutation conferring artemisinin resistance in this locus.
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