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These data suggest that the PCHAS_031370 T719N mutation confers an increased CQ-R phenotype.
The V600E mutation confers an increase in BRAF kinase activity of approximately 480 times compared with wild-type BRAF, whereas the V600D mutation increases this by approximately 700 times (Wan et al, 2004).
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This mutation confers a poor prognosis in the metastatic setting, and a high risk of cancer recurrence as seen in several studies [6 9].
The triple mutation confers a three-fold increase in sensitivity to ciprofloxacin in vitro and similar sensitivities to a range of other quinolones.
(e) All mutations are 'equal' such that no mutation confers a survival advantage or disadvantage to the cell harboring it.
The dbf4-ΔN221 dbf4-ΔN221onfers a domutationheconfers bypass.
BRCA1 mutation confers a higher incidence of ovarian cancer than does BRCA2 mutation [ 26].
Fourth, the BoxG18A mutation confers a small but significant disadvantage during competition for glucosamine (GlcN).
The data presented here show that, in P. chabaudi, a single point mutation confers a distinct shift in artemisinin responses.
This mutation confers a 49% lifetime risk of breast cancer and 18% lifetime risk for ovarian cancer [ 40].
In fact, the V299L mutation was later detected in this patient and might explain this clinical course, as this mutation confers a poorer efficacy for dasatinib [ 16].
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