As shown below (see section on Muller's ratchet with selfing), a simple scaling of mutation rate and selection coefficient is enough to extend the standard model of Muller's ratchet to this case.
P was approached here by the proportion of nonsynonymous mutations whose population selection coefficient is between 0 and −1.
A window with a low coefficient is better at blocking heat than a window with a higher coefficient.
If that is also equal, coefficient is the clincher.
"The coefficient is incredibly important.
Its temperature coefficient is 0.04.
Where mutation selection coefficients are exponentially distributed, the inferred distribution of haplotype fitnesses is close to being correct.
Theoretically, it is expected that effective population size will be the major factor determining gene diversity even at a locus under balancing selection, if the mutation rate and selection coefficient are constant [ 5- 7].
For each set of observed marker frequencies, a deterministic curve, parameterized by a mutation time and a selection coefficient, was fitted.
Moreover, in comparison to a population remaining stable at the initial size, fewer new genetic variants are generated and beneficial mutations with a given selection coefficient are more likely to be lost in a declining population (Otto and Whitlock 1997).
