The probability of replication of a variant i results in variant j is given by q ij and then these mutation coefficients obey.
In our model, gene duplicates tend to buffer deleterious mutations (the coefficient selection of a mutation is divided by the copy number).
The residues, at the positions having higher position mutation correlation coefficients (see Table 1), are indicated by green frames.
The 27 mutative positions with higher mutation correlation coefficients distribute in two α-helices, all 6 β-strands, and some loops, including the easily mutative positions and some very conservative positions [33].
Where mutation selection coefficients are exponentially distributed, the inferred distribution of haplotype fitnesses is close to being correct.
Wt: Wild type; Mut: Mutation; r: Correlation coefficient.
Consider a new adaptive mutation with selection coefficient s > 0 in a panmictic haploid population of constant size N.
In this approximation, a target mutation of selection coefficient σ is subject to interference by stronger selective sweeps at a total rate V > = ∫ σ ∞ d σ ′ V drive.
This time scale is determined by a "scaling factor" that is a function of the mutation rate, selection coefficient, and effective population size.
