Sentence examples for mutation causes embryonic from inspiring English sources

Homozygous allelic combination of this mutation causes embryonic lethality.

This mutation causes embryonic lethality at 25° because of failure of mitotic spindle alignment, chromosome congression defects, and mitotic spindle collapse within 1 min of temperature upshift; thus, the phenotype most likely does not involve changes in posttranslational regulation of gene expression (Schmidt et al. 2005).

Smo mutation caused embryonic lethality.

Therefore, it remains to be proven whether all equine dominant white mutations cause embryonic lethality in the homozygous state.

Both mutations cause embryonic phenotypes similar to efa-6 RNAi (O'Rourke et al., 2010) and display similarly enhanced axon regrowth (Chen et al., 2011).

Notably, these mutations cause embryonic lethality, but normal early development can be restored in mutant embryos by treating them prenatally with MEK inhibitors (Inoue et al., 2014), which is also the case for zebrafish models generated by mRNA injection of human BRAF variants with CFC-causing mutations (Anastasaki et al., 2009, 2012).

According to Smyth et al. [ 29], null mutation of LAMC1 causes embryonic lethality because of the absence of the basement membrane and failure to differentiate the endoderm.

Mutation of Spen in mice causes embryonic lethality (Kuroda et al., 2003), which might be partly attributable to a repressive function in the Notch signaling pathway (Yabe et al., 2007).

Of a total of 149 progeny, no live pups homozygous for the 129-derived allele or displaying enlarged eyes have been found, suggesting that homozygosity of the Ppcd1 mutation or a closely linked gene causes embryonic lethality.

Total LIS1 loss causes embryonic lethality, but deletion or point mutation inactivating one LIS1 allele causes lissencephaly, an autosomal-dominant disorder of neuronal migration.

Indeed, defective development in the early embryonic stages causes embryonic lethality in Pomt1 mutant mice [23].