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This promoter region mutation caused higher level of expression of phoH2 in vitro but lower expression in macrophages in H37Ra than H37Rv (Figure 2).
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The G20210A prothrombin gene mutation causes higher levels of prothrombin which leads to increased generation of thrombin and thrombophilia [ 13].
In this paper, we propose a novel mechanism for the development of muscular dystrophy: POMT mutation causes high myoblast density and position derangement, which result in apoptosis, muscle disorganization, and muscle cell defects.
K103N mutation causes high resistance to NVP and EFV (26), as found in our study, although we have not been able to sequence all our samples.
Both sets of mutations caused high-level, constitutive expression (Figure 3B) when compared to the un-mutated acuR-lacZ fusion, consistent with these being in the cis-acting operator site to which the AcuR repressor binds.
The study results from Sordella et al. also supported that EGF-independent autophosphorylation in these mutations caused high sensitivity to gefitinib and selectively activated downstream pathways [ 39].
Human XP-D patients show severe phenotypes, and mutations in the Drosophila genes hay and mrn, encoding the cTFIIH component Xpb and p52, respectively, have many visible phenotypes, and even under normal, unchallenged growth conditions, mutations cause higher apoptotic levels that lead to the development of defective wings (Merino et al., 2002; Fregoso et al., 2007).
The epigenetic and genetic variations are assumed to be abstracted into the levels of phosphoprotein activation (i.e., PTEN inactivating mutations causing higher levels of p-Akt) with differences in unmeasured pathways across cell lines being sources of error in the model.
To exclude the possibility of drug resistance mutations impacting on the entropy calculations, epitopes containing amino acid positions known to acquire mutations causing high, intermediate or low level resistance to RT and protease inhibitors (Stanford University Drug Resistance database) were removed from the list of epitopes and all the calculations were repeated.
With the exception of L100I, these mutations cause high-level resistance to nevirapine.
When heterozygous, mtrm mutations cause high levels of achiasmate chromosome nondisjunction (Harris et al. 2003; Xiang et al. 2007).
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